Vacancies at Computational Biophysics

PostDoc position (3 years)

We have an open position for a postdoc (3 years) working on particle-based computer simulations that aid in the interpretation of experiments on atomic force microscopy (AFM) imaging, nanomechanical bending and nano-indentation on individual fibrillar protein aggregates and the mesoscopic gels they form. The objective is to gain a better fundamental understanding of, and insight into, the relation between (i) the molecular properties of the individual protein molecule and the structural and mechanical properties of the resulting fibrillar structures and (ii) the properties of these fibrillar structures and the mechanical, structural and rheological properties of the solution of entangled, semi-flexible fibers on a mesoscopic scale. Two types of computer simulations are planned. In the first type we plan to simulate the bulk rheology of entangled networks given the structural and mechanical properties of its constituent fibrils. This will help us in creating a comprehensible link between the structural and mechanical properties on the different length scales. The second type of simulation will simulate the actual nano-indentation experiment, which will aid in understanding how to deduce the rheological parameters from the force distance curves obtained.

The candidate is expected to further develop and apply a mesoscopic fluid method, called Stochastic Rotation Dynamics (or Multi-Particle Collision Dynamics) in order to simulate both Brownian motion of, and hydrodynamic interactions between, biopolymer chain segments and a large AFM sphere. Besides with other members of the Computational Biophysics group, the candidate will collaborate with Dr. Martin Bennink of the Biophysical Engineering group (also University of Twente) who will lead the experiments, and with Dr. Johan Padding (Universite de Louvain, Belgium) who has initiated the development of the proposed simulation method.

Prospective candidates should have a PhD in physics, chemistry, or related subject, with a proven track record in programming, developing and using particle based simulation methods, with no more than 4 years of previous postdoc experience. The candidate should be proficient in Statistical Physics. Please do not apply if you do not have the above experience.

Knowledge of hydrodynamic interactions, rheology and/or (bio)polymers will be considered an advantage. Please send your application, with a curriculum vitae showing relevant experience, to Prof. Wim Briels.